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Atazanavir Sulphate

Atazanavir Sulphate

Original price was: ₹200.00.Current price is: ₹150.00.

Applications

Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).

Description

Atazanavir Sulfate is a sulfate salt form of atazanavir, an aza-dipeptide analogue with a bis-aryl substituent on the (hydroxethyl)hydrazine moiety with activity against both wild type and mutant forms of HIV protease. Atazanavir does not elevate serum lipids, a common problem with other protease inhibitors.

Preparation

According to an aspect of the present invention, there is provided a process for the preparation of Compound (A) that comprises preparing atazanavir sulphate by treating atazanavir base (Compound (II)) with sulphuric acid in a combination of solvents, and isolating Compound (A).

Chemical Properties

Atazanavir sulfate is a white to pale yellow crystalline powder with low solubility in water, known for its antiviral properties, and is a vital component in the treatment of HIV infection.

Definition

Atazanavir sulfate is a sulfated derivative of atazanavir, a protease inhibitor used in the treatment of HIV/AIDS by inhibiting the HIV protease enzyme.

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Description

Product Name Atazanavir Sulphate
Brand indian
Country of Origin Made in India
Usage Pharma
Formula C38H54N6O11S
Molar Mass 704.856 g/mol
CAS ID 198904-31-3
Elimination half-life 6.5 hrs
Bioavailability 68%
Molecular Weight 802.94
Melting point 195.0°, or acetone; mp 198-199° (dec)
alpha D22 -46.1° (c = 1 in 1:1 CH3OH/H2O, pH = 2.6)
storage temp under inert gas (nitrogen or Argon) at 2-8°C
solubility ≥28.7 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥4.05 mg/mL in EtOH with gentle warming and ultrasonic
form Powder
Packaging Size As Per Requirement

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