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Adefovir Dipivoxil Api

Adefovir Dipivoxil Api

Original price was: ₹2,500.00.Current price is: ₹2,250.00.

Applications

Adefovir dipivoxil is a nucleoside analogue used for chronic hepatitis B infection, including against lamivudine-resistant strains. It is administered as the oral prodrug (plasma t½ 8 h, intracellular t½ of active metabolite 17 h).

Description

Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.

Preparation

The synthesis of adefovir dipivoxil is completed by addition of the chloromethyl pivalate to a solution of the corresponding phosphonic acid in N-methylpyrrolidone (NMP), using triethylamine as base. Figure 2. Synthetic scheme of crystalline adefovir dipivoxil.

Chemical Properties

Adefovir dipivoxil API is a white to off-white crystalline powder with low solubility in water, recognized for its antiviral properties in treating chronic hepatitis B by inhibiting viral DNA polymerase.

Definition

Adefovir dipivoxil API is an organic compound used in the treatment of chronic hepatitis B, functioning as a nucleotide analogue inhibiting viral DNA replication.

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Description

Product Name Adefovir Dipivoxil Api
Country of Origin Made in India
Usage Pharma
CAS ID 142340-99-6
Formula C8H12N5O4P
Molar Mass 273.186 g/mol
Protein Binding 4%
Elimination half-life 7.5 hrs
Molecular Formula C20H32N5O8P
Molecular Weight 501.47
Melting point 98-102°C
Boiling point 641.0±65.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility ethanol: soluble50mg/mL
pka 4.16±0.10(Predicted)
form solid
color White to Off-White
Packaging Size As Per Requirement

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