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5-amino-2- Methyl Benzene Sulfonamide
  1. 5-amino-2- Methyl Benzene Sulfonamide

5-amino-2- Methyl Benzene Sulfonamide

Original price was: ₹1,200.00.Current price is: ₹1,000.00.

Applications

5-Amino-2-methylbenzenesulfonamide is an intermediate for the synthesis of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Description

5-Amino-2-methylbenzenesulfonamide is an intermediate for the synthesis of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Preparation

The invention relates to a preparation method of 2-methyl-5-aminobenzenesulfonamide, which comprises the following steps: s1 sulfonation: dissolving paranitrotoluene and chlorosulfonic acid in an organic solvent I, stirring for reaction, and performing post-treatment to obtain 2-methyl-5-nitrobenzenesulfonyl chloride; s2 hydrogenation addition reaction: adding the 2-methyl-5-nitrobenzenesulfonyl chloride in the step S1 into a hydrogenation kettle, sequentially adding a catalyst, ammonia water and an organic solvent II, reacting at high temperature and high pressure, and treating after reaction to obtain light yellow solid 2-methyl-5-aminobenzenesulfonamide. The method has the advantages of short route, high product purity and easy industrial production.

Chemical Properties

Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 98.0 area% Purity(Nonaqueous Titration) min. 98.0 %
Melting point 165.0 to 170.0 °C

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Description

PRODUCT 5-AMINO-2- METHYL BENZENE SULFONAMIDE
FORMULA CH3OC6H3(NH2)SO3H
CAS NO 6470-17-3
MOLECULAR Weight 203.22
APPEARANCE (COLOR) WHITE TO TAN POWDER, CRYSTALS, CRYSTALLINE
APPEARANCE (FORM) POWDER AND/OR CHUNKS
Melting point 163-164℃
Boiling point 421.5±55.0 °C(Predicted)
Density 1.359±0.06 g/cm3(Predicted)
storage temp Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 10.43±0.60(Predicted)
form Solid
color Pale Beige
Stability Hygroscopic
Packaging Size As Per Requirement

PRODUCT : 5-AMINO-2- METHYL BENZENE SULFONAMIDE

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