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2,4-Diamino-6-Hydroxypyrimidine

2,4-Diamino-6-Hydroxypyrimidine

Original price was: ₹8,400.00.Current price is: ₹8,300.00.

Applications

2,4-Diamino-6-hydroxypyrimidine is a selective inhibitor of GCH-I (GTP cyclohydrolase I). Suppression of this enzyme by 2,4-Diamino-6-hydroxypyrimidine impedes tetrahydrobiopterin biosynthesis and abolishes both lipopolysaccharide-induced elevation of biopterin levels and lipopolysaccharide-induced NO synthesis.

Description

2,4-Diamino-6-hydroxypyrimidine is a selective inhibitor of GCH-I (GTP cyclohydrolase I). Suppression of this enzyme by 2,4-Diamino-6-hydroxypyrimidine impedes tetrahydrobiopterin biosynthesis and abolishes both lipopolysaccharide-induced elevation of biopterin levels and lipopolysaccharide-induced NO synthesis.

Preparation

After the sodium has dissolved, the solution is cooled and 113 g. (1 mole) of ethyl cyanoacetate is added (Note 1). This mixture is allowed to stand while a second solution of sodium ethoxide of the same volume and concentration is prepared. To this solution is added 97 g.

Chemical Properties

2,4-Diamino-6-hydroxypyrimidine is a crystalline solid with potential reactivity at amino and hydroxyl groups, important in pharmaceutical synthesis as a building block for various drugs.

Definition

2,4-Diamino-6-hydroxypyrimidine is an organic compound with the chemical formula C4H6N4O, featuring a pyrimidine ring substituted with amino groups and a hydroxyl group, commonly used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals.

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Description

Product Name 2,4-Diamino-6-Hydroxypyrimidine
CAS Number 56-06-4
Country of Origin Made in India
Usage Pharma
Formula C15H14N2O2
Molecular Weight 254.28 g/mol
Manufacturer Sihauli
Melting point 285-286 °C (dec.) (lit.)
Boiling point 234.22°C (rough estimate)
Density 1.3659 (rough estimate)
refractive index 1.7990 (estimate)
storage temp Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 10.61±0.50(Predicted)
form Fine Crystalline Powder
color White to cream
Sensitive Light Sensitive
Packaging Size As Per Requirement

Our Export Location as a 2,4-Diamino-6-Hydroxypyrimidine Manufacturer, Supplier, Exporter, Stockist from India.

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